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Recently is suggested a possible contribution of infectious nature in the etiopathogeny of the degenerative aortic stenosis (AE). The main characteristic of the AE is its calcificacion and the implied pathogenies up to now, as Chlamydia pneumoniae and others, they do not justify the existence of calcificacions. Recently there has been described a new bacterial specie called sanguineum Nanobacterium with aptitude to precipitate calcium in the shape of crystals of apatite. The nanobacteries have been observed in renal calculations, in carotids, and in aortic aneurysms. We have isolated the nanobacteries from aortic valvels of patients with aortic stenosis subjected to the change of their valves. In the laboratory of microbiology the valves were cultivated in environment DMEM with bovine fetal serum for culture of nanobacteries, incubating in 37 ºC for 4-6 weeks. The control group was formed by aortic valves from both patients with pure aortic insufficiency and transplanted patients. The main percentage of positive cellular cultures in patients with aortic stenosis suggests that these microorganisms might contribute directly in the fisiopathogenic mechanism responsible for the typical valve calcificacion of this pathology
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